The NYU RNAi Core provides an integrated, state-of-the-art, RNA interference (RNAi) based high-throughput screening (HTS) facility at the NYU Langone Medical Center. The core is committed to offering siRNA/dsRNA screening libraries for the cross-species functional characterization of whole genomes in a systematic, comprehensive, and cost effective manner. In addition, the facility may also provide logistic, technical, and bioinformatic support in order to assist screeners in performing and interpreting their genome scale RNAi screens. Importantly, we are strongly committed to making the NYU RNAi Core fully accessible to the entire academic community**, both at the national and international level, in order to facilitate inter-disciplinary and multi-institutional collaborations.
The core offers the following siRNA/dsRNA libraries for HTS:
• Human annotated genome (siRNA library from Ambion)
• Human pre-miR and anti-miR miRNA collection (from Ambion)
• Mouse genome (siRNA library from Ambion)
• Drosophila whole genome and functional group subsets (dsRNA libraries in collaboration with DRSC, Harvard Medical School)**
• C. elegans whole genome (2 bacterial feeding libraries from Vidal and Ahringer collections)
We have also agreed to share resources with the Rockefeller University High-Throughput Screening Resource Center (HTSRC) so that NYU users will have access to chemical screening through the HTSRC.
** The Drosophila libraries are access-restricted to researchers in the New York-tri-state area; others are requested to contact DRSC, Harvard Medical School.
